Diffuse toxic goiter, or Graves disease, Basedova - endocrine pathology, which is characterized by hyperfunction and hyperplasia of the thyroid gland.
Causes of the disease can serve many factors.
Symptoms are pronounced.
Diffuse toxic goiter: symptoms
At the heart of the pathogenesis of the disease may lieViolation of immune surveillance, in which the formation of autoantibodies with a stimulating effect that inevitably leads to hyperthyroidism with subsequent hyperplasia and hypertrophy. In addition, hereditary factors, chronic infections, intoxications, psychological trauma are of great importance.
The main symptoms of diffuse toxic goiter:
- Frequent mood changes-
- Tremor of the hands-
- Increased fatigue-
- Weight loss with increased appetite-
- Atrial fibrillation-
- Disruption of the gastrointestinal tract-
- Pre-toxic mixadem, when there is thickening of the skin on the front side of the feet and shin-
- Decreased potency-
- Violation of the menstrual cycle-
It is worth noting, not always in the presence of diffuseToxic goiter there is a decrease in weight. Some patients gain a sufficient amount of extra pounds, and Basedova disease occurs against the background of obesity.
Diagnosis of diffuse toxic goiter
The referral is given by a doctorEndocrinologist. Ultrasound shows that the thyroid gland has a diffuse increase, eye exophthalmos without trophic disorders are observed. Looking down, the upper eyelids lag behind the movements of the eyeball. With a neurologic examination, the patient is shown the instability of Romberg's position, hyperreflexia.
A blood test shows a significant decreaseCholesterol level, increased iodine content, low level of triiodothyronine, thyroxine and thyroid-stimulating hormone. In any doubtful situation, when the exact diagnosis is still in question, the patient is given a trial with tiroroliberin.
If the level of thyroid-stimulating hormone does not increase when the samples are taken, the toxic diffuse goiter is confirmed.
Treatment of diffuse toxic goiter
As a treatment, medicamentous orSurgical methods. The doctor selects an effective dose of thyreostatic drugs, appoints radioactive iodine. If the effect of replacement therapy is absent, atrial fibrillation worries, all other symptoms of the disease are amplified, surgery or radioiodine therapy is indicated.